14q32/miRNA Clusters loss of heterozygosity in acute lymphoblastic leukemia is associated with up-regulation of BCL11a
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چکیده
منابع مشابه
Expression of ROR1 Gene in Patients with Acute Lymphoblastic Leukemia
Background: Acute lymphoblastic leukemia (ALL) results from genetic alterations in a single lymphoid progenitor cell. Expression of ROR1 is reported to be increased in ALL and mantle cell lymphoma. In this study the expression of ROR1 was assessed in newly diagnosed patients with ALL. Methods: This study was carried out on 40 patients with newly diagnosed ALL and healthy individuals as contro...
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TEL is a new member of the ETS family of transcription factors which is rearranged in a number of hematologic malignancies with translocations involving chromosome band 12p13. In some cases, both TEL alleles are affected, resulting in loss of wild-type TEL function in the leukemic cells. In addition, 5% of children with acute lymphoblastic leukemia (ALL) have 12p12-p13 deletions, suggesting tha...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2010
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.21758